San Francisco 49ers 38-10 Arizona Cardinals: Jimmy Garoppolo throws four TDs as 49ers win in Mexico

The 49ers (6-4) are number one in the NFC West with the Seahawks after their third straight win; Watch Thanksgiving NFL Triple Header – Bills @ Lions, Giants @ Cowboys and Patriots @ Vikings – Live on Sky Sports NFL, 5:30 pm Sunday

Jimmy Garoppolo set a career high with four touchdowns as the San Francisco 49ers beat the Arizona Cardinals 38-10 on Monday night in Mexico City.

Garoppolo completed 20 of 29 passes for 228 yards and made two TD passes to receiver Brandon Aiyuk and tight end George Kittle. San Francisco’s other touchdown came on a superb 39-yard run by stellar distanced Deebo Samuel.

The Cardinals (4-7) played without starting quarterback Kyler Murray for the second consecutive game due to a hamstring injury.

Veteran Colt McCoy, who led Arizona to victory over the defending Super Bowl champion Los Angeles Rams last week, had no such luck at Estadio Azteca. McCoy was 24 of 34 passes for 218 yards with one interception.

The Cardinals were up 3-0 after one quarter on Matt Prather’s 40-yard field goal before the 49ers started shooting. Garoppolo threw a seven-yard TD pass to Aiyuk and a 39-yard pass to Kittle before Arizona scored their only touchdown on James Conner’s two-yard run.

49ers 0-3 cardinals Matt Prather 40-yard field goal
49ers 7-3 cardinals Jimmy Garoppolo’s seven-yard TD pass to Brandon Aiyuk (extra point)
49ers 14-3 cardinals Jimmy Garoppolo 39 yard pass to George Kittle (extra point)
49ers 14-10 cardinals James Conner Two Yard Run TD (extra point)
49ers 17-10 cardinals Robbie Gould 39-yard field goal
49ers 24-10 cardinals Deebo Samuel 39-yard touchpad run (extra point)
49ers 31-10 cardinals Jimmy Garoppolo 13 yard pass to Brandon Aiyuk (extra point)
49ers 38-10 cardinals Jimmy Garoppolo 32 yard pass to George Kittle (extra point)

Robbie Gould hit a 39-yard field goal with 43 seconds left in the half to make it 17-10 for the 49ers before halftime. Samuel then scored on San Francisco’s opener in the second half before Garoppolo landed two more scoring hits, hitting Aiyuk from 13 yards and Keetl from 32 to seal the route.

The game was a rematch of the 2005 competition at the same stadium, which was the first NFL regular season game played outside the United States.

Niners quarterback Jimmy Garoppolo: “When you have playmakers like we do, it allows you to do everything.

“It’s just a ‘what-the-protection-will-try-to-take’ question.” If they try to take a run in the middle of the field, we will throw it out. We have a lot of playmakers in this offense and it makes my job easier when they are around.

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